Allegra M., Carletti F., Gambino G., Tutone M., Attanzio A., Tesoriere L., Ferraro G., Sardo P., Almerico A. M., Livrea M. A., Indicaxanthin from Opuntia ficus-indica Crosses the Blood–Brain Barrier and Modulates Neuronal Bioelectric Activity in Rat Hippocampus at Dietary-Consistent Amounts, Journal of Agricultural and Food Chemistry, 2015, 63(33):7353-7360, doi: 10.1021/acs.jafc.5b02612
A study of indicaxanthin in rats that includes measurement of the pigment in the brain after oral administration, recordings from hippocampal neurons during local microiontophoresis and modelling of interaction with the NMDA receptor. The results describe pharmacokinetics and the acute electrophysiological response in an animal model.